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Declining estrogen and progesterone, combined with relative androgen dominance, can trigger diffuse thinning across the scalp
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19–22 These genetic polymorphic sites include rs3333631, rs763035, and rs111314066, which can exacerbate the inflammatory response in patients with rosacea by upregulating the expression of factors related to inflammatory pathways, such as Toll-like receptors and the JAK3 pathway
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