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Targeting these pathways enables senolytic therapies to specifically induce programmed cell death in senescent cells while sparing non-senescent, healthy cells, hence enhancing healthspan and mitigating age-related diseases.49 In contrast to conventional anti-aging therapies that just decelerate the aging process, senolytics actively eradicate dysfunctional cells, thereby rejuvenating tissues and improving physiological function.50 Mechanisms of Action of Senolytics Senolytics exert their effects by targeting the key survival pathways that allow senescent cells to evade apoptosis

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3.2 Imbalance of the sex hormones in PCOS 3.2.1 Androgen The primary etiology and symptoms of PCOS are predominantly associated with the dysregulation of steroid hormones, particularly elevated levels of androgen and decreased progesterone levels linked to luteal phase deficiency