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According to the POLAR study, intravenous administration of calmangafodipir and oxaliplatin was too close in time, which may lead to unfavorable redox interactions between Mn2 + and Pt 2 , while administration of calmangafodipir 10 min before the start of oxaliplatin infusion in previous mouse studies as well as in a phase II clinical trial (PLIANT) could avoid destructive interactions between calmangafodipir and oxaliplatin [158]
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