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However, this is not an FDA-approved standard, and any use should be discussed with a qualified provider first

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The treatment policy estimand evaluated the treatment effect for all randomised subjects regardless of trial product discontinuation and use of rescue medication (data analysed using multiple imputation), whereas the trial product estimand evaluated the treatment effect for all randomised subjects under the assumption that they remained on the trial product for the entire planned duration of the trial and did not use rescue medication (data analysed using a mixed model for repeated measures) [28]