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The most widely accepted model postulates that inducers, all of which react with sulfhydryl groups [11], modify highly reactive cysteine residues of the sensor Keap1 [42] which then loses its ability to target Nrf2 for degradation

ing-s-acetyl-l-glutathione

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However, PrDxs have now been identified as ubiquitous enzymes in numerous organisms, involved in the neutralization of H 2 O 2 , alkyl hydroperoxides (ROOH), and ONOO − [259,260,261]