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Mechanistically, efferocytosis involves panoplies of molecules, among which Mer receptor tyrosine kinase (Mertk), a phagocytic cell-surface receptor, is implicated in driving adhesion and internalization of ACs during efferocytosis
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Because a key limitation for PROTAC development has been the identification of ligands specific for proteins of interest, the use of proteins and peptide binders, which can be highly specific and genetically encoded, could alleviate this limitation and thus expand the scope of PROTACs
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