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Many different hypotheses have been given from time to time to elucidate the causative factors of this disease in order to explain the multifactorial nature of disease such as cholinergic hypothesis, Aβ hypothesis, tau hypothesis, oxidative stress hypothesis and inflammation hypothesis [24]
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Notably, this suggests that the hematopoietic response to folic acid in pernicious anemia would not occur if folic acid had been converted to 5-methylTHF in the process of intestinal absorption
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