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If, as one post-mortem studies suggest [81], glutamate concentrations in different cortical layers can vary in opposite direction in schizophrenia, the restricted spatial resolution is an even more critical limitation (even the available 1 mm3 resolution of most other MRI techniques cannot yet address this hurdle)

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Regardless of microbial translocation, chronic tissue injury, including persistent endothelial dysfunction, can also release endogenous damage signals from dying/compromised cells, thus leading to systemic oxidative stress and inflammasome activation (81)