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Electrolyte Imbalance and BUN Increases Patients receiving triamterene and hydrochlorothiazide should be carefully monitored for fluid or electrolyte imbalances, i.e., hyponatremia, hypochloremic alkalosis, hypokalemia and hypomagnesemia

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If significant GI symptoms occur, slower titration, temporary dose reduction, or interruption may be necessary, with monitoring of renal function