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Over the course of 10 h, GTP was completely hydrolyzed as indicated by the emergence of free phosphate (1.51 ppm), the new α-phosphoryl (−10.78 ppm) and β-phosphoryl (−2.00 ppm) signals 66 of the KRAS-Q61R)·GDP· 1 complex, and the disappearance of GTP peaks (Fig
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Although we now know that glaucoma can occur even in people with normal IOP, this is still the most common underlying symptom of the disease
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