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When taken orally, it primarily interacts with the gut lining, which may be helpful in models of: Ulcer healing ( Stark et al., 2017 ) Inflammatory bowel conditions ( Sikiric et al., 2015 ) Intestinal barrier protection ( Stark et al., 2017 ) However, oral peptides are subject to breakdown by stomach acid and digestive enzymes, which can limit their absorption into the bloodstream ( Sikiric et al., 2015 )