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This is corroborated with other markers of apoptosis such as cleaved caspase-3, apoptosis inducing factor (AIF) and CCAAT-enhancer-binding protein homologous protein (CHOP) trending towards increases during ESHP, but generally not being significantly increased ( Supraphysiologic glucose and insulin provision as a contributor to ESHP pathophysiology One can appreciate that donor organs, once implanted in the recipient, last for years as opposed to a matter of hours on a machine perfusion apparatus