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Crosslinking of FcαRI by IgA-containing immune complexes, resulting in sustained receptor aggregation, induces potent activating signalling through immunoreceptor tyrosine-based activation motifs, whereas FcαRI binding by monomeric IgA, resulting in low-valency interactions and unsustained receptor aggregation, induces inhibitory signalling 27

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R 13 , R 14 , R 15 , and R 16 are each independently H, or C 1 -C 4 alkyl