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Research has demonstrated that AGEs can trigger cellular senescence via several mechanisms, including the initiation of p21 in an oxidative stress-dependent manner, upregulation of p16 expression, inhibition of autophagy by diminishing PINK1/Parkin activity, and the promotion of inflammation in renal cells (Liu et al., 2014
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[PubMed] [Google Scholar] 76.Takeda T.A., Mu A., Tai T.T
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