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Once in the bloodstream, cibinetide binds this receptor on immune cells (especially myeloid cells like macrophages and microglia), endothelial cells, and other stressed tissues, triggering intracellular signaling (e.g., JAK/STAT, PI3K/Akt, and inhibition of NF-κB p65) that dampens innate immune overactivation, suppresses production and systemic release of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-12/IL-23), reduces chemokine-driven cell infiltration, lowers oxidative stress and nitric oxide overproduction, and promotes anti-inflammatory shifts and cell survival

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Volume:10mg – 10 vial lab pack (Save 10%)

Apr2022;15(4):433-442