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References Gastrointestinal adverse events associated with GLP-1 RA in non-diabetic patients with overweight or obesity, a systematic review and network meta-analysis of 39 studies and 33,354 individuals, International Journal of Obesity Safety profile of tirzepatide in real world clinical practice, a pharmacovigilance study of 123,145 FAERS reports reporting a median 13 day time to onset, Diabetes, Obesity and Metabolism Tirzepatide once weekly for the treatment of obesity, the SURMOUNT-1 phase 3 randomized trial in 2,539 adults reporting gastrointestinal events primarily during dose escalation, New England Journal of Medicine Acute small bowel obstruction induced by tirzepatide, a case report describing conservative management with nasogastric decompression and no recurrence at two months, Cureus Targeted ileal bile acid transporter inhibition as rescue therapy for tirzepatide induced severe constipation, a case report in which added fiber and several laxatives had failed, Case Reports in Gastroenterology Official FDA label for ZEPBOUND (tirzepatide) published on DailyMed, reporting constipation in 17%, 14% and 11% of patients at 5 mg, 10 mg and 15 mg against 5% on placebo, and listing fecal impaction, ileus and intestinal obstruction under postmarketing experience Official FDA label for WEGOVY (semaglutide 2.4 mg) published on DailyMed, reporting constipation in 24% of treated adults against 11% on placebo in the adult obesity and overweight trials