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That N-terminal region is exactly where IGFBPs make their primary contact with the IGF-1 molecule, so removing it sharply reduces binding-protein affinity as well — through subtraction rather than extension
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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Zhu Y., Pan W.H., Ku C.F., Zhang H.J., Tsang S.W
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