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IGF-I acts predominantly via the IGF-I receptor (IGF-IR), a transmembrane protein consisting of two extracellular α-subunits, which contain the IGF-I binding site, and two transmembrane β-subunits that have a cluster of three tyrosine residues, which undergo phosphorylation and activation upon IGF-I binding to mediate canonical signaling pathways necessary for cell survival and growth
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Supportingly, a reduction of reserpine-hypothermia (NaBPC157 pre-treatment) and reversal of further prominent temperature fall (NaBPC157 post-treatment) have been consistently observed
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