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This enzyme has a key role in angiogenesis and is essential for progressing diseases such as solid tumors and rheumatoid arthritis
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NOX4 is the only NOX isoform identified with mitochondrial localization [113], and it can be postulated that NOX4-derived H 2 O 2 in obesity and diabetes promotes excess mitochondrial ROS production, a phenomenon termed ROS-induced ROS release [200]
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