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The proliferation of genital skin fibroblasts can be stimulated by IGF-1, thus suggesting a possible in vivo role for this growth factor but no effects were observed on AR levels.38 ARs identical to those found in RPSMC have been found in cultures of smooth muscle cells from human penis and clitoris.39 A considerable number of mutations of the human AR gene have been identified which decrease or suppress the expression of AR protein or render it nonfunctional3640 while some of them are responsible for penile growth arrest and the subsequent development of micropenis or ambiguous genitalia

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This substance induced proptosis in a certain species of fish, and in later studies, proptosis was induced in guinea pigs or mice following injection with TSH or pituitary extract