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These effects were compared to those of untreated controls that were also maintained on a high-fat diet
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Posttranslational modifications include the removal of the N-terminal signal sequence (converting pre-procollagen into procollagen), hydroxylation of specific proline (Pro) and lysine (Lys) residues—the process requiring molecular oxygen, Fe 2+ ions, and ascorbic acid—and glycosylation of selected hydroxylysine residues
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