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However, despite these promising effects, reports regarding tBHQ’s genotoxicity (Eskandani et al., 2014), pro-oxidative behavior (Imhoff and Hansen, 2010), and potential carcinogenicity (Gharavi et al., 2007) diminished its therapeutic appeal
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In HT-1080 fibrosarcoma cells, overexpression of SLC7A11 was found to increase resistance to ferroptosis, while its knockdown made cells more susceptible to ferroptosis (38)
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