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sinensis may rely on an alternative reductive metabolic pathway for cordycepin biosynthesis (Figure 1): AMP is converted to ADP by adenylate kinase (ADEK), then reduced to 3′-dADP by ribonucleotide reductase (NRDJ), followed by dephosphorylation to 3′-dAMP by ADEK, and finally converted to cordycepin through a dephosphorylation reaction catalyzed by 5′-nucleotidase (NT5E)