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Treatment of Anemia in HIV Patients | Evidence Based Findings

It should be noted that this use should only be considered under the guidance of a doctor

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Incubation with ascorbate (as a source of hydrogen peroxide, which will oxidise GSH to GSSG) or acetylphenylhydrazine, which also oxidises GSH to GSSG, leads to a considerable increase in the activity of the pentose phosphate pathway, suggesting that the need for increased activity of the pathway is the need for NADP to reduce GSSG back to GSH – or, more correctly, the presence of a relative excess of NADP+ to be reduced to NADPH