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Furthermore, downregulation of the purine catabolism enzyme xanthine dehydrogenase increases TGF-β2/3 and phosphorylated Smad2/3 levels and contributes to EMT and cell migration in hepatocellular carcinoma cell lines ( Concluding Remarks As summarized above, TGF-β signaling can exert its cellular and physiological effects through reprograming of cell metabolism
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However, how this concentration gradient of HAM is defined in the developing meristem and continually maintained in the established SAMs remains to be elucidated
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