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If this receptor does exist in the mitochondrial membrane, it could help to explain the high efficiency of melatonin in protecting this organelle from oxidative damage, e.g., by mediating the upregulation of mitochondrial antioxidative enzymes
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Preclinical studies have demonstrated the efficacy of ferroptosis inducers, such as erastin and RSL3, in sensitizing NSCLC cells to chemotherapy and radiotherapy ( Despite the promising preclinical results, the clinical translation of ferroptosis research faces several challenges
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