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Damage to the blood-brain barrier (BBB) in the CNS around the site of inflammation can result in an uncontrolled release of metalloproteinases, inflammatory cytokines, and proteases and the inappropriate activation and dysfunction of endothelial cells and extravasation of oedema fluid into the interstitial space [9]
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While some studies report GSO 2 H to be still reversible by cellular means, GSO 3 H is always described as irreversible 23
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