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Glutathione peroxidase 4 (GPX4) is an enzyme that converts active GSH to GSSG by replacing lipid hydroperoxide (LOOH) with a lipid hydroperoxyl radical (LOO), which is a glucose-6-phosphate dehydrogenase (G6PD) of pentose phosphate

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However, due to the potential for these medications to induce cognitive decline, especially in elderly patients, their usage has become less common in recent years