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In breast cancer, CBD-induced apoptosis is accompanied by down-regulation of the mammalian target of rapamycin (mTOR), which regulates cell proliferation and apoptosis, cell cycle, and localization of PPARγ in the nuclei and cytoplasmic of the tested cells [154]
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Dendritic cells also produce IL-36, creating an autocrine loop that further amplifies inflammation [30]
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