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Step 2: Reduce Mechanical Stress Treatment may include activity changes, manual care, decompression-based treatment, positioning, and gentle movement

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Based on both genetic and pharmacological methods, we recruited four major groups, including two rich of 5-HT groups (WT and KO+5-HTP groups) and two deficient of 5-HT groups (WT+PCPA and KO groups), to ensure the reliability of the experimental results