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each R 2 is independently selected from C 6 -C 10 aryl, or 5-10 membered heteroaryl, where each said C 6 -C 10 aryl, or 5-10 membered heteroaryl is optionally substituted with halogen, cyano, OR 8 , NR 8 R 9 , C 1 -C 6 alkyl, C 1 -C 6 heteroalkyl, C 3 -C 6 cycloalkyl, or 3-6 membered heterocyclic
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In the resulting dicistronic cassettes co-expression of 3CD alongside P1 was regulated using a PV3-derived internal ribosome entry site (PV-IRES)
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