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Several Bruton tyrosine kinase (BTK) inhibitors are in phase III clinical trials for nonrelapsing secondary progressive multiple sclerosis, eg, tolebrutinib and remibrutinib
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The conjugation of GHK to several cofactors has been used as a strategy to (i) increase the stability of the tripeptide towards the protease action, (ii) enlarge the number of biological functions, and (iii) improve the delivery to specific targets [16]
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