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In addition, many other researchers found that radiotherapy might affect ferroptosis by mediating the expression of iron metabolism-related proteins such as iron ion-related carriers like ferritin, FPN, regulatory iron regulators, membrane iron transport auxiliary protein (Hephaestin) and copper cyanobacteria by mediating hypoxia-inducible factor 1α (HIF-1α) or HIF-2α (Shah et al., 2009
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Unnecessary injections also expose patients to injection-related complications and rare hypersensitivity reactions without a clearly established therapeutic benefit
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