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In AD, however, elevated brain iron drives microglia toward a ferroptosis-prone state, marked by upregulated heme oxygenase-1 and enhanced release of inflammatory mediators like IL-1β (140, 141)
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In this condition of viral infection, oxidative stress is imposed by GSH depletion, occurring in two steps and following direct virus challenge of the cell membrane, without the intervention of ROS (Ciriolo et al., 1997)
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