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Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme | Nature Communications

Identification of dihydrofuro[3,4- d ]pyrimidine derivatives as novel HIV-1 nonnucleoside reverse transcriptase inhibitors with promising antiviral activities and desirable physicochemical properties

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When this organic acid increases in the blood, H⁺ increases ↓ HCO₃⁻ is used for buffering ↓ HCO₃⁻ ↓ ↓ Unmeasured anions derived from 5-oxoproline ↑ ↓ Anion Gap ↑ In other words, because 5-oxoproline increases as an "unmeasured anion," the anion gap widens