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The general idea is that the circadian machinery may significantly impair the adaptive anti-tumor immune responses through the attenuation of T cell homing to the lymph nodes and the reduction of APC-T cell interaction with consequent reduction in T cell activation, an event essential for killing cancer cells
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[145] [146] A re-evaluation of the claims in 1982 found that the patient groups were not actually comparable, with the vitamin C group being less sick on entry to the study, and judged to be "terminal" much earlier than the comparison group
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