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The study cohort was formed of patients with at least one administration of the IvIg IgPro10 during the entire study period

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Metabolites were extracted with ice-cold 80% methanol supplemented with 20 μM deuterated 2-hydroxyglutarate (D-2-hydroxyglutaric2,3,3,4,4-d5 acid (d5–2HG)) as an internal standard