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An in vitro study using unstimulated mouse lung alveolar epithelial cells showed a constitutive association between GSTP1-1 and IκBα, and resulted in the inhibition of NF-κB, potentially by preventing the phosphorylation and ubiquitination of IκBα
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An alternative approach that has been explored experimentally in the porcine ischemic injury model to limit formation of LA inhibitory fragments while maintaining the ability of LA to induce recovery of barrier function involves addition of small doses of LA over time and suggest that 0.1 μM LA applied every 45 min is effective (49)
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