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Another study in 12 patients with primary RLS and vitamin D deficiency demonstrated a significant and clinically meaningful reduction in RLS severity (IRLS score of 26 [range = 15–35] to 10 [range = 0–27]) after vitamin D3 supplementation (28,000 IU/week oral or 200,000 IU/month intramuscular with calcium carbonate and maintenance dose of 400 IU/day) that were continued until levels were corrected [34]