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Metabolic characteristics include: Plasma half-life of 11-12 minutes after either intravenous or subcutaneous administration Very rapid clearance rates of 2.4-2.8 L/min in adult subjects Degradation primarily through peptidase enzymes in plasma and tissues No accumulation observed even with repeated daily dosing The extremely short half-life reflects the peptide’s susceptibility to proteolytic cleavage at multiple sites along its amino acid sequence

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Classical mucolytics, like NAC and other thiol reducing agents, degrade the three-dimensional network that forms the mucus by reducing the disulphide bonds (S-S) to a sulfhydryl (SH) bond (-SH) that no longer participates in the cross-linking