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By interfering with this interaction, FOXO4-DRI is proposed to release p53 from FOXO4-mediated sequestration, allowing p53 to translocate to the mitochondria and trigger apoptosis selectively in senescent cells while sparing non-senescent cells
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Briefly, The [ 18 F]F- was trapped on a QMA cartridge and then eluted with 80:20% acetonitrile/water solution (1.0 mL) containing kryptofix2.2.2 (12.0 mg) and K 2 CO 3 (1.0 mg) to a V-vial (Wheaton) to produce potassium [18F]fluoride/kryptofix2.2.2
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