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Omega-3 fatty acids can competitively inhibit AA metabolism, and compete with AA to bind COX-2 and LOX enzymes through EPA, reducing the production of pro-inflammatory mediators' prostaglandin E2 and leukotriene B4 (72)
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In lung cancer cell line models, the HMOX1 gene has increased SMARCA4 suppression of NRF2 binding to transcriptional regulatory regions and increased gene expression 23
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