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community uses 4–12 weeks with breaks Human evidence None — preclinical (cell, mouse) only Regulatory status Not FDA-approved
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Reactions were performed with 0.5 µM catechol substrate COMT-S01, 1 µM radiolabelled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human COMT enzyme
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