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4.2 Iron depletion methods Free iron can catalyze the production of ROS in Fenton reaction, and excessive production of ROS in the presence of iron overload can lead to oxidative stress and damage DNA, lipids, and proteins ( DFO is a clinically used iron chelator derived from streptomyces polymyxa and is a hexadentate complex that forms a 1:1 Fe 3+ /DFO complex at physiological PH
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