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Also, the addition of polyethylene glycol to the surface of the liposomes gives the liposomes a hydrophilic โsterically stabilizedโ surface, a property that contributes to a lower affinity of macrophages of the mononuclear phagocyte system (MPS) for the circulating liposome particles and consequently to an even extended prolonged blood circulation (more than 5-fold prolongation of liposome circulation time in blood) [127]
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