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A MTHFR variant can lead to a shortage of the active form of folate within the body, which may affect the conversion of homocysteine to methionine
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But in general, these folks are more likely to be B12 deficient: vegetarians or vegans people taking certain medications (like metformin, Prilosec, or Pepcid) pregnant and breastfeeding people people over 50 people with atrophic gastritis, celiac disease, Crohn’s disease, or who have had stomach or intestinal surgery Which form of vitamin B12 is best
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