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however, most blood samples are collected with a small amount of a much cheaper reagent, sodium fluoride, in the sample-collection vial

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Iron deficiency per se and iron deficiency-induced hypoxia can trigger the activation of HIFs, which are known to mediate cancer progression by upregulating target genes associated with angiogenesis and the metabolic reprogramming of tumor cells (106, 107), thus causing resistance to chemo- and radiotherapies (108, 109)